And while PHAs are tolerable with other ingredients, start off easy by pairing them with gentle, base products before use. “The two big ingredients to avoid while integrating PHAs into your skin routine are vitamin C and retinol,” emphasizes Dr. Henry. “If you mix Vitamin C with PHAs and they are not formulated properly, they may negate the efficacy of both. Retinol if mixed with PHAs can result in unpredictable irritation,” she explains.
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